• Aziz S Alali, David Gomez, Victoria McCredie, Todd G Mainprize, and Avery B Nathens.
• Sunnybrook Research Institute, Sunnybrook Health Sciences Center, Toronto, Ontario, Canada.
• Neurosurgery. 2017 Apr 1; 80 (4): 534-542.

BackgroundThe hospital volume-outcome relationship in severe traumatic brain injury (TBI) population remains unclear.ObjectiveTo examine the relationship between volume of patients with severe TBI per hospital and in-hospital mortality, major complications, and mortality following a major complication (ie, failure to rescue).MethodsIn a multicenter cohort study, data on 9255 adults with severe TBI were derived from 111 hospitals participating in the American College of Surgeons Trauma Quality Improvement Program over 2009-2011. Hospitals were ranked into quartiles based on their volume of severe TBI during the study period. Random-intercept multilevel models were used to examine the association between hospital quartile of severe TBI volume and in-hospital mortality, major complications, and mortality following a major complication after adjusting for patient and hospital characteristics. In sensitivity analyses, we examined these associations after excluding transferred cases.ResultsOverall mortality was 37.2% (n = 3447). Two thousand ninety-eight patients (22.7%) suffered from 1 or more major complication. Among patients with major complications, 27.8% (n = 583) died. Higher-volume hospitals were associated with lower mortality; the adjusted odds ratio of death was 0.50 (95% confidence interval: 0.29-0.85) in the highest volume quartile compared to the lowest. There was no significant association between hospital-volume quartile and the odds of a major complication or the odds of death following a major complication. After excluding transferred cases, similar results were found.ConclusionHigh-volume hospitals might be associated with lower in-hospital mortality following severe TBI. However, this mortality reduction was not associated with lower risk of major complications or death following a major complication.Copyright © 2017 by the Congress of Neurological Surgeons

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