• Giannis Sokratous, Ismail Ughratdar, Richard Selway, Safa Al-Sarraj, and Keyoumars Ashkan.
• Department of Neurosurgery, King's College Hospital, London, United Kingdom. Electronic address: giannis.sokratous@nhs.net.
• World Neurosurg. 2017 Jun 1; 102: 696.e7-696.e11.

BackgroundRapid growth in cerebral cavernous malformation is rare. A review of the literature revealed 4 patients with known cerebral cavernous malformations who later developed a high-grade glioma at the same site. All 4 patients were females, ranging in age from 25 to 71 years, with imaging confirming rapid growth in the lesion.Case DescriptionWe present the case of a 71-year-old patient with known multiple cavernomas over many years in whom one lesion showed rapid expansion in size. Histological examination revealed the coexistence of a glioblastoma within the cavernoma.ConclusionsWe conclude that, although rare, rapid expansion of an existing cavernoma should be considered suspicious for the development of other malignant tumors, and propose adding chronic inflammation in the surrounding brain caused by microbleeds and hemosiderin deposition from the cavernoma to the list of possible causes.Copyright © 2017 Elsevier Inc. All rights reserved.

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