• Pain management · Sep 2015

    Meta Analysis

    Regional anesthesia/analgesia and the risk of cancer recurrence and mortality after prostatectomy: a meta-analysis.

    • Brenda M Lee, Vinny Singh Ghotra, Jose A Karam, Mike Hernandez, Greg Pratt, and Juan P Cata.
    • Department of General Surgery, John Hopkins Hospital, MD, USA.
    • Pain Manag. 2015 Sep 1; 5 (5): 387-95.

    AimsTo determine whether the use neuraxial anesthesia/analgesia is associated with longer biochemical recurrence-free survival (BRFS) and overall survival (OS) after radical prostatectomy.MethodsTen studies were included in the meta-analysis. A random-effects model was used to estimate the hazard ratios (HRs).ResultsThe HR for BRFS was 1.02 (95% CI: 0.91-1.15) for all studies and 1.08 (95% CI: 0.91-1.15) for those that included propensity score matching. For OS, the HR across all studies was 0.91 (95% CI: 0.7-1.15) and 0.81 (95% CI: 0.68-0.96; p = 0.016) for those reporting propensity score matching.ConclusionThe anesthetic technique used during oncologic prostatectomy surgery is not associated with longer BRFS. By contrast, the use of regional analgesia appears to improve OS.

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