• Burns · Nov 2017

    Review

    The role of complement in the acute phase response after burns.

    • H Ibrahim Korkmaz, KrijnenPaul A JPAJDepartment of Pathology, VU University Medical Center, Amsterdam, The Netherlands; Institute of Cardiovascular Research (ICaR-VU), VU University Medical Center, Amsterdam, The Netherlands., UlrichMagda M WMMWDepartment of Pathology, VU University Medical Center, Amsterdam, The Netherlands; Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands; Association of Dutch Burn Centres (ADBC), B, E de Jong, van ZuijlenPaul P MPPMDepartment of Plastic, Reconstructive and Hand Surgery, MOVE Research Institute, VU University Medical Center, Amsterdam, The Netherlands; Burn Center and Department of Plastic and Reconstructive Surgery, Red Cross Hospital, Beverwij, and NiessenHans W MHWMDepartment of Pathology, VU University Medical Center, Amsterdam, The Netherlands; Department of Cardiac Surgery, VU University Medical Center, Amsterdam, The Netherlands; Institute of Cardiovascular Research (ICaR-VU), VU University Med.
    • Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands; Institute of Cardiovascular Research (ICaR-VU), VU University Medical Center, Amsterdam, The Netherlands. Electronic address: h.korkmaz@vumc.nl.
    • Burns. 2017 Nov 1; 43 (7): 1390-1399.

    AbstractSevere burns induce a complex systemic inflammatory response characterized by a typical prolonged acute phase response (APR) that starts approximately 4-8h after-burn and persists for months up to a year after the initial burn trauma. During this APR, acute phase proteins (APPs), including C-reactive protein (CRP) and complement (e.g. C3, C4 and C5) are released in the blood, resulting amongst others, in the recruitment and migration of inflammatory cells. Although the APR is necessary for proper wound healing, a prolonged APR can induce local tissue damage, hamper the healing process and cause negative systemic effects in several organs, including the heart, lungs, kidney and the central nervous system. In this review, we will discuss the role of the APR in burns with a specific focus on complement.Copyright © 2017 Elsevier Ltd and ISBI. All rights reserved.

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