• Faheem W Guirgis, Lisa Jones, Rhemar Esma, Alice Weiss, Kaitlin McCurdy, Jason Ferreira, Christina Cannon, Laura McLauchlin, Carmen Smotherman, Dale F Kraemer, Cynthia Gerdik, Kendall Webb, Jin Ra, Frederick A Moore, and Kelly Gray-Eurom.
• University of Florida College of Medicine, Jacksonville, Department of Emergency Medicine, Jacksonville, FL, USA. Electronic address: Faheem.Guirgis@jax.ufl.edu.
• J Crit Care. 2017 Aug 1; 40: 296-302.

PurposeSepsis can lead to poor outcomes when treatment is delayed or inadequate. The purpose of this study was to evaluate outcomes after initiation of a hospital-wide sepsis alert program.Materials And MethodsRetrospective review of patients ≥18years treated for sepsis.ResultsThere were 3917 sepsis admissions: 1929 admissions before, and 1988 in the after phase. Mean age (57.3 vs. 57.1, p=0.94) and Charlson Comorbidity Scores (2.52 vs. 2.47, p=0.35) were similar between groups. Multivariable analyses identified significant reductions in the after phase for odds of death (OR 0.62, 95% CI 0.39-0.99, p=0.046), mean intensive care unit LOS (2.12days before, 95%CI 1.97, 2.34; 1.95days after, 95%CI 1.75, 2.06; p<0.001), mean overall hospital LOS (11.7days before, 95% CI 10.9, 12.7days; 9.9days after, 95% CI 9.3, 10.6days, p<0.001), odds of mechanical ventilation use (OR 0.62, 95% CI 0.39, 0.99, p=0.007), and total charges with a savings of $7159 per sepsis admission (p=0.036). There was no reduction in vasopressor use (OR 0.89, 95% CI 0.75, 0.1.06, p=0.18).ConclusionA hospital-wide program utilizing electronic recognition and RRT intervention resulted in improved outcomes in patients with sepsis.Copyright © 2017 Elsevier Inc. All rights reserved.

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