• Eur J Anaesthesiol · Aug 2013

    Effects of balanced hydroxyethyl starch solutions on gut mucosal microcirculation and exhaled nitric oxide in septic rats: A randomised, animal study.

    • Kristina Langanke, Jürgen Hinkelmann, Lars G Fischer, Hugo K Van Aken, Andreas W Sielenkamper, Christian Ertmer, and Hendrik Freise.
    • Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital of Münster, Münster, Germany.
    • Eur J Anaesthesiol. 2013 Aug 1;30(8):469-75.

    ContextBalanced hydroxyethyl starch (HES) solutions with a molecular weight of 130 kDa (tetrastarches) are frequently used in clinical practice. These solutions are derived either from waxy maize or potato starch and they are not bioequivalent.ObjectivesInvestigation of the effects of waxy maize-derived and potato-derived starches on intestinal microcirculation and pulmonary inflammation in experimental sepsis.DesignA randomised (three groups), blinded animal study.SettingAnimal experimental facility in a university hospital.AnimalsTwenty-one male Sprague-Dawley rats weighing 275 to 300 g.InterventionSepsis was induced by caecal ligation and puncture. Animals received balanced crystalloid infusion (6 ml kg h) for 23 h followed by randomised 1 h bolus infusion (30 ml kg h) of crystalloid: balanced crystalloid solution or waxy maize starch: 6% wt/vol HES 130/0.4 or potato starch: 6% wt/vol HES 130/0.42. Results are presented as median (interquartiles).Main Outcome MeasuresUsing intravital microscopy, mucosal perfusion was assessed by intercapillary area (ICA) between all perfused capillaries (ICAtotal) and continuously perfused capillaries only (ICAcont). Mucosal blood flow was calculated from arteriolar diameter and red blood cell velocity. Intestinal wall 3-nitrotyrosine (3-NTint) content and exhaled nitric oxide (exNO), to indicate pulmonary inflammation, were measured.ResultsBoth tetrastarches improved capillary perfusion compared to the crystalloid group, as indicated by reduced ICAtotal [crystalloid 1054 (905 to 1211) μm; waxy maize starch 789 (744 to 940) μm, P <0.05; potato starch 674 (536 to 693) μm, P < 0.05] and reduced ICAcont [crystalloid 1060 (996 to 1340) μm; waxy maize starch 860 (793 to 975) μm, P <0.05; potato starch 701 (558 to 728) μm, P <0.05]. Mucosal blood flow and systemic blood pressure did not differ significantly between groups. 3-NTint was comparable among all groups. exNO was significantly reduced from 11.1 (5.0 to 16.5) ppb to 4.2 (4.0 to 4.8) ppb in the waxy maize group, whereas no significant difference was detected in the potato starch group 6.2 (4.8 to 10.5).ConclusionBolus infusion of balanced 6% wt/vol tetrastarches augments mucosal capillary perfusion. Pulmonary inflammation in sepsis is differentially influenced by tetrastarches produced from different raw materials.

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