• Anesthesia and analgesia · May 2017

    Comparative Study Observational Study

    Blood Bupivacaine Concentrations After a Combined Single-Shot Sciatic Block and a Continuous Femoral Nerve Block in Pediatric Patients: A Prospective Observational Study.

    • Santhanam Suresh and Gildasio S De Oliveira.
    • From the *Department of Anesthesiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois; and †Department of Anesthesiology, Northwestern University, Chicago, Illinois.
    • Anesth. Analg. 2017 May 1; 124 (5): 1591-1593.

    AbstractWe evaluated blood bupivacaine concentrations in children having a single-shot sciatic and continuous femoral blocks after anterior cruciate ligament repair. Dried blood spot samples were analyzed for bupivacaine levels at 0, 5, 15, 30, 60, and 120 minutes and 4, 24, and 48 hours. The highest 99% upper confidence interval limit was 135 ng/mL at the 4-hour evaluation point. The 99% upper confidence interval was below potentially toxic levels (1500 ng/mL) across all sampling times. The risk of local anesthetic toxicity in pediatric patients receiving single-shot sciatic and continuous femoral nerve blocks is very low.

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