• Dunja Mihajlovic, Snezana Brkic, Arsen Uvelin, Biljana Draskovic, and Vladimir Vrsajkov.
• Medical faculty, University of Novi Sad, Clinical center of Vojvodina, Emergency center, Department of anesthesia and reanimation, Novi Sad, Serbia. Electronic address: dunja.mihajlovic@mf.uns.ac.rs.
• J Crit Care. 2017 Aug 1; 40: 197-201.

PurposeThere is a need for identification of marker that could lead physicians to take the right step towards laboratory techniques for documentation of infection. The aim of this study was to investigate whether presepsin and procalcitonin (PCT) levels in patients with suspected sepsis could predict blood culture (BC) and SeptiFast (SF) results.Material And Methods100 patients were included in our study. PCT, C-reactive protein (CRP), and presepsin levels were determined. Differences between groups of patients were assessed by Mann-Whitney U test. Categorical variables were compared using chi-square test. Receiver operating characteristic (ROC) curves were plotted to determine predictive values of biomarkers for prediction of positive SF results.ResultsPCT (70.9±106.36 vs. 16.35±26.79) and presepsin (4899.73±5207.81 vs. 1751.59±2830.62) were significantly higher in patients with positive SF in contrast to patients with negative SF. There was no significant difference between patients who had positive and negative BC for PCT and presepsin values. PCT and presepsin showed a similar performance in predicting positive SF results with AUC of 0.75 for PCT and 0.73 for presepsin.ConclusionPresepsin can serve as good predictor of bacteremia detected by SF and it should be included with PCT in protocols for sepsis diagnosing.Copyright © 2017 Elsevier Inc. All rights reserved.

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