• Vaccine · Dec 2007

    Case Reports

    Fatal multiorgan failure due to yellow fever vaccine-associated viscerotropic disease.

    • Jon L Belsher, Peter Gay, Margo Brinton, Joseph DellaValla, Robert Ridenour, Robert Lanciotti, Andrey Perelygin, Sherif Zaki, Christopher Paddock, Troy Querec, Tuofu Zhu, Bali Pulendran, Rachel B Eidex, and Edward Hayes.
    • Mayo Clinic College of Medicine, Rochester, MN, United States.
    • Vaccine. 2007 Dec 5; 25 (50): 8480-5.

    AbstractYellow fever vaccine-associated viscerotropic disease (YEL-AVD) is a rare complication of yellow fever (YF) vaccination. A previously healthy 22-year-old female died following YF vaccination despite aggressive measures. Serial viral load titers, cytokine levels and host genetic factors were evaluated in an attempt to understand this unusual and lethal outcome. The patient's high-titer vaccine viremia and possibly related minor genetic anomalies provide clues to exploring the etiology of YEL-AVD.

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