• Helene Beloeil, Barthelemy Sion, Chloe Rousseau, Pierre Albaladejo, Mathieu Raux, Frederic Aubrun, Valeria Martinez, and SFAR research network.
• From the CHU Rennes, Pôle Anesthésie et Réanimation, Inserm, UMR 991, CIC 1414 and Université de Rennes 1 (HB), CHU Rennes, Pôle Anesthésie et Réanimation (BS), CHU Rennes, Inserm CIC 1414, Rennes (CR), Pôle Anesthésie Réanimation CHU de Grenoble BP217, Grenoble Cedex 9 (PA), Département d'Anesthésie Réanimation, AP-HP, Groupe Hospitalier Pitié-Salpêtrière Charles Foix, Paris (MR), Hospices civils de Lyon, Université Lyon 1, Groupement hospitalier Nord, Hôpital de la Croix Rousse, Lyon (FA), Service d'Anesthésie Réanimation Chirurgicale, Hôpital Raymond Poincaré, AP-HP (VM); and INSERM, U-987, Hôpital Ambroise Paré, Centre d'Evaluation et de Traitement de la Douleur, Paris, France (VM).
• Eur J Anaesthesiol. 2017 Oct 1; 34 (10): 652-657.

BackgroundAcute neuropathic pain can occur in the postoperative period but any link with persistent post-surgical neuropathic pain remains unclear.ObjectivesThe objectives of this study were to prospectively describe the incidence of acute post-surgical neuropathic pain in a large population using the DN4 (clinician administered) questionnaire and to confirm the hypothetical link between acute and persistent neuropathic pain at 2 months after surgery in a large population using the DN2 (self administered) questionnaire.DesignA multi-centre, prospective and observational trial.SettingTwo consecutive days in 27 hospitals in France.PatientsSix hundred and eight patients undergoing 13 different types of surgery. Fifteen patients were excluded as data were incomplete, and 229 (38.6%) and 260 (43.8%) were not contactable for assessment at 1 and 2 months after surgery, respectively.Main Outcome MeasuresPain was evaluated at least 2 h postoperatively on the same day (D0),on the second day (D2) and at 1 and 2 months after surgery (M1 and M2). Pain was assessed using a 10-point Numeric Rating Scale. If the Numeric Rating Scale score was greater than 0, neuropathic pain was assessed using a DN4 (clinician administered) questionnaire or using a DN2 (self-administered) questionnaire. Acute and persistent postsurgical neuropathic pain (PPSNP) were defined respectively by a DN4 score at least 4/10 on day 0 and/or day 2 and a DN2 score at least 3/7 at 2 months after surgery.ResultsOf the 593 patients included, 41.2% were in pain before surgery and 8.2% described neuropathic pain. Early after surgery, the majority of the 593 patients (72.2% on the day of surgery and 71.3% on day 2) experienced acute pain. It was neuropathic in nature in 5.6% of patients (95% CI, 3.6 to 8.3) on the day of surgery and 12.9% (95% CI, 9.7 to 16.7) on day 2. Two months after surgery, PPSNP was present in 33.3% of the 333 patients assessed. Multivariate analysis showed that a DN4 score at least 4/10 on the day of surgery or on day 2 was a significant risk factor for PPSNP [odds ratios 4.22 (95% CI, 2.19 to 8.12)].ConclusionOur results suggest that early acute postsurgical neuropathic pain significantly increases the risk of persistent post-surgical neuropathic pain.Trial RegistrationClinicaltrials.gov identifier: NTC NCT02826317.

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