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Neurobiology of aging · Nov 2015
Mutation analysis of CHCHD2 gene in Chinese familial Parkinson's disease.
- Zhenhua Liu, Jifeng Guo, Kai Li, Lixia Qin, Jifeng Kang, Li Shu, Yuan Zhang, Yang Wei, Nannan Yang, Yang Luo, Qiying Sun, Qian Xu, Xinxiang Yan, and Beisha Tang.
- Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
- Neurobiol. Aging. 2015 Nov 1; 36 (11): 3117.e7-8.
AbstractFunayama et al. recently identified mutations in the CHCHD2 gene in Japanese families with autosomal dominant Parkinson's disease, increasing our knowledge about the monogenic cause of this disorder. However, there is no report regarding the association between CHCHD2 and Parkinson's disease (PD) in the Chinese Han population. The aim of this study was to obtain the prevalence of CHCHD2 mutations in Chinese familial PD. Genetic analysis of mutations in CHCHD2 gene was conducted in a cohort of 92 families with autosomal dominant Parkinson's disease from mainland China. No mutations in CHCHD2 gene were identified, suggesting that CHCHD2 mutations might not be a common cause of PD in Chinese familial cases.Copyright © 2015 Elsevier Inc. All rights reserved.
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