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- J B Bicking, J H Jones, W J Holtz, C H Robb, F A Kuehl, D H Minsker, and E J Cragoe.
- J. Med. Chem. 1978 Oct 1; 21 (10): 1011-8.
AbstractThe synthesis of a series of 8-acetyl- (or 1-hydroxyethyl-) 12-hydroxy-13-aryloxytridecanoic acids and their sulfonamide isosteres is described. These compounds are formally derived from members of earlier reported series of modified secoprostaglandins by replacing the omega-butyl chain termini by substituted aryloxy groups. A number of these compounds are potent inhibitors of collagen-induced blood platelet aggregation in guinea pigs on oral administration.
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