• J Pain · Sep 2017

    Randomized Controlled Trial Multicenter Study

    A longitudinal randomized trial of the impact of consistent pain management for infant vaccinations on future vaccination distress.

    • Anna Taddio, Riddell Rebecca Pillai RP Department of Psychology, York University, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada., Moshe Ipp, Steven Moss, Stephen Baker, Jonathan Tolkin, Malini Dave, Sharmeen Feerasta, Preeya Govan, Emma Fletcher, Horace Wong, Caitlin McNair, Priyanjali Mithal, and Derek Stephens.
    • Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada; Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address: anna.taddio@utoronto.ca.
    • J Pain. 2017 Sep 1; 18 (9): 1060-1066.

    AbstractThe objective was to determine if consistent pain management during vaccine injections has a beneficial effect on future infant pain reactivity. This was a multicenter, longitudinal, double-blind, double-dummy, add-on, randomized controlled trial. Healthy infants were randomized to 1 of 4 add-on pain management regimens for all vaccinations in the first year of life: 1) placebo control (standard care), 2) parent video education about infant soothing (video), 3) video and oral sucrose solution (sucrose), 4) video and sucrose and topical liposomal lidocaine (lidocaine). At 15-month vaccinations, all active pain interventions were administered (video and sucrose and lidocaine); however, individuals remained blinded to the original treatments given. Pain at 15 months was evaluated during 3 procedure phases (baseline, needle injection, and recovery) by a researcher unaware of group allocation using a validated measure, the Modified Behavioural Pain Scale (range, 0-10). Altogether, 352 infants participated; characteristics did not differ among groups (P > .05). Pain scores did not differ among groups during baseline (P = .642), needle injection (P = .739), or recovery (P = .750) phases. In conclusion, there was no evidence of a long-term benefit of consistent use of pain interventions in the first year of life on future infant pain responsivity at 15-month vaccinations.Copyright © 2017 American Pain Society. Published by Elsevier Inc. All rights reserved.

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