• Pierre-Grégoire Guinot, Louise Badoux, Eugénie Bernard, Osama Abou-Arab, Emmanuel Lorne, and Hervé Dupont.
• Anaesthesiology and Critical Care Department, Amiens University Hospital, Place Victor Pauchet, Amiens, France; INSERM U1088, Jules Verne University of Picardy, Amiens, France. Electronic address: guinotpierregregoire@gmail.com.
• J. Cardiothorac. Vasc. Anesth. 2017 Aug 1; 31 (4): 1190-1196.

ObjectiveThe objective of this study was to assess the association between increased central venous-to-arterial carbon dioxide difference (ΔPCO2) following cardiac surgery with cardiopulmonary bypass and postoperative morbidity and mortality.DesignA prospective, observational, non-interventional study.PatientsThree hundred ninety-three patients undergoing cardiac surgery with cardiopulmonary bypass.InterventionsThe primary endpoint was the occurrence of one or more major postoperative complications. A ΔPCO2 ≥ 6 mmHg was considered to be abnormal. Data were first analyzed globally, and then according to 4 subgroups based on time course of ΔPCO2 during the study period: [(1) persistently normal ΔPCO2; (2) increasing ΔPCO2; (3) decreasing ΔPCO2; and (4) persistently high ΔPCO2].ResultsA total of 238 of the 393 (61%) patients developed complications. The major postoperative complication rate did not differ among the 4 groups: 64% (n = 9) in group 1, 62% (n = 21) in group 2, 53% (n = 32) in group 3, and 62% (n = 176) in group 4 (p = 0.568). Mortality rates did not differ among the 4 groups (p > 0.05). ΔPCO2 was correlated weakly with perfusion parameters.ConclusionsThese results suggested that ΔPCO2 is not predictive of postoperative complications or mortality.Copyright © 2017 Elsevier Inc. All rights reserved.

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