• Paediatric anaesthesia · May 1997

    Case Reports

    Repair of ventricular septal defect in a child with severe pulmonary hypertension-response to inhaled nitric oxide.

    • Nuala Cregg and William Casey.
    • Department of Anaesthesia,Children's Research Centre, Our Lady's Hospital for SicChildren, Crumlin, Dublin 12, Ireland.
    • Paediatr Anaesth. 1997 May 1; 7 (3): 255-258.

    AbstractNitric oxide (NO), was administered successfully, to a child with severe pulmonary hypertension, following surgical repair of a large ventricular septal defect. Inhalation of NO, 20-25 parts per million (ppm) was continued for 24 h, resulting in mean pulmonary artery pressure (PAP) of 25 mmHg and permitting a reduction in both ventilatory and inotropic support. Weaning of NO was commenced. At 5 ppm, administration was discontinued. An immediate and dramatic increase in PAP occurred. A similar pattern resulted on further attempts, demonstrating the extreme sensitivity of the pulmonary vasculature to the effects of inhaled low dose NO and the selectivity of the response.1997 Blackwell Science Ltd.

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