• Mary K Sandquist, Mark S Clee, Smruti K Patel, Kelli A Howard, Toni Yunger, Usha D Nagaraj, Blaise V Jones, Lin Fei, Sudhakar Vadivelu, and Hector R Wong.
• 1Division of Pediatric Critical Care, University of Louisville, Norton Children's Hospital, Louisville, KY. 2Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. 3Department of Neurosurgery, University of Cincinnati Medical Center, Cincinnati, OH. 4Division of Neuroradiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. 5Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. 6Division of Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
• Pediatr Crit Care Me. 2017 Jul 1; 18 (7): 607-613.

ObjectivesThis study was intended to describe and correlate the neuroimaging findings in pediatric patients after sepsis.DesignRetrospective chart review.SettingSingle tertiary care PICU.PatientsPatients admitted to Cincinnati Children's Hospital Medical Center with a discharge diagnosis of sepsis or septic shock between 2004 and 2013 were crossmatched with patients who underwent neuroimaging during the same time period.InterventionsAll neuroimaging studies that occurred during or subsequent to a septic event were reviewed, and all new imaging findings were recorded and classified. As many patients experienced multiple septic events and/or had multiple neuroimaging studies after sepsis, our statistical analysis utilized the most recent or "final" imaging study available for each patient so that only brain imaging findings that persisted were included.Measurements And Main ResultsA total of 389 children with sepsis and 1,705 concurrent or subsequent neuroimaging studies were included in the study. Median age at first septic event was 3.4 years (interquartile range, 0.7-11.5). Median time from first sepsis event to final neuroimaging was 157 days (interquartile range, 10-1,054). The most common indications for final imaging were follow-up (21%), altered mental status (18%), and fever/concern for infection (15%). Sixty-three percentage (n = 243) of final imaging studies demonstrated abnormal findings, the most common of which were volume loss (39%) and MRI signal and/or CT attenuation abnormalities (21%). On multivariable logistic regression, highest Pediatric Risk of Mortality score and presence of oncologic diagnosis/organ transplantation were independently associated with any abnormal final neuroimaging study findings (odds ratio, 1.032; p = 0.048 and odds ratio, 1.632; p = 0.041), although early timing of neuroimaging demonstrated a negative association (odds ratio, 0.606; p = 0.039). The most common abnormal finding of volume loss was independently associated with highest Pediatric Risk of Mortality score (odds ratio, 1.037; p = 0.016) and oncologic diagnosis/organ transplantation (odds ratio, 2.207; p = 0.001) and was negatively associated with early timing of neuroimaging (odds ratio, 0.575; p = 0.037).ConclusionsThe majority of pediatric patients with sepsis and concurrent or subsequent neuroimaging have abnormal neuroimaging findings. The implications of this high incidence for long-term neurologic outcomes and follow-up require further exploration.

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