• J. Thorac. Cardiovasc. Surg. · Dec 2017

    Pulmonary function tests do not predict mortality in patients undergoing continuous-flow left ventricular assist device implantation.

    • Edo K S Bedzra, Todd F Dardas, Richard K Cheng, Jay D Pal, Claudius Mahr, Jason W Smith, Kent Shively, S Carolina Masri, Wayne C Levy, and Nahush A Mokadam.
    • Division of Cardiothoracic Surgery, University of Washington Medical Center, Seattle, Wash. Electronic address: ebedzra@uw.edu.
    • J. Thorac. Cardiovasc. Surg. 2017 Dec 1; 154 (6): 1959-1970.e1.

    ObjectivesTo investigate the effect of pulmonary function testing on outcomes after continuous flow left ventricular assist device implantation.MethodsA total of 263 and 239 patients, respectively, had tests of forced expiratory volume in 1 second and diffusing capacity of the lungs for carbon monoxide preoperatively for left ventricular assist device implantations between July 2005 and September 2015. Kaplan-Meier analysis and multivariable Cox regressions were performed to evaluate mortality. Patients were analyzed in a single cohort and across 5 groups. Postoperative intensive care unit and hospital lengths of stay were evaluated with negative binomial regressions.ResultsThere is no association of forced expiratory volume in 1 second and diffusing capacity of the lungs for carbon monoxide with survival and no difference in mortality at 1 and 3 years between the groups (log rank P = .841 and .713, respectively). Greater values in either parameter were associated with decreased hospital lengths of stay. Only diffusing capacity of the lungs for carbon monoxide was associated with increased intensive care unit length of stay in the group analysis (P = .001). Ventilator times, postoperative pneumonia, reintubation, and tracheostomy rates were similar across the groups.ConclusionsForced expiratory volume in 1 second and diffusing capacity of the lungs for carbon monoxide are not associated with operative or long-term mortality in patients undergoing continuous flow left ventricular assist device implantation. These findings suggest that these abnormal pulmonary function tests alone should not preclude mechanical circulatory support candidacy.Copyright © 2017 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.

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