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Mediators of inflammation · Jan 2006
Detection of salivary interleukin 2 and interleukin 6 in patients with burning mouth syndrome.
- Daria Simcić, Sonja Pezelj-Ribarić, Renata Grzić, Jelena Horvat, Gordana Brumini, and Miranda Muhvić-Urek.
- School of Dentistry, Medical Faculty, University of Rijeka, 51000 Rijeka, Croatia.
- Mediators Inflamm. 2006 Jan 1; 2006 (1): 54632.
AbstractThe etiology of BMS remains unknown. Role of various cytokines has been implicated in the development of BMS. The aim of this study was to evaluate levels of salivary IL-2 and IL-6 in patients with BMS, compared with age-matched healthy volunteers (control group). Whole saliva from 30 patients with BMS, age range 55-65, was tested for the presence of IL-6 and IL-2 by enzyme immunoassay. Control group consisted of 30 healthy participants, aged 55-65 years. Saliva IL-2 concentrations in BMS were significantly increased in patients compared to healthy subjects: mean 34.1 +/- 9.7 versus 7.3 +/- 3.0 pg/mL; P < .001. Patients with BMS had significantly higher concentrations of IL-6 compared to control: mean 30.8 +/- 5.6 versus 5.2 +/- 2.8 pg/mL; P < .001. In patients with BMS, IL-2 and IL-6 levels in saliva are elevated, correlating with the severity of illness.
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