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Case Reports
Hyperkalemia and cardiac arrest associated with glucose replacement in a patient on spironolactone.
- Ryan Offman, Amanda Paden, Adam Gwizdala, and James Fletcher Reeves.
- Mercy Health - Muskegon, Department of Emergency Medicine, Muskegon, MI, United States. Electronic address: ryan.offman@mercyhealth.com.
- Am J Emerg Med. 2017 Aug 1; 35 (8): 1214.e1-1214.e3.
AbstractWe present a case of hypoglycemia, which after intravenous glucose replacement, led to cardiac arrest secondary to a profound extracellular potassium shift. The patient was on spironolactone therapy which is known to cause aldosterone resistance (which inhibits the body's ability to prevent potassium shifts) [1]. Physicians typically review medications that cause hypoglycemia, but other medications may interfere with potassium homeostasis with administration of glucose. Knowledge of this case may prompt further monitoring, repeat lab testing, and careful medication reconciliation before discharging a patient with risk for aldosterone resistance. On our literature review, we have not found additional reports where this particular physiology led to cardiac arrest.Copyright © 2017 Elsevier Inc. All rights reserved.
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