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- Michael A van Es, Orla Hardiman, Adriano Chio, Ammar Al-Chalabi, R Jeroen Pasterkamp, Jan H Veldink, and Leonard H van den Berg.
- Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands.
- Lancet. 2017 Nov 4; 390 (10107): 208420982084-2098.
AbstractAmyotrophic lateral sclerosis is characterised by the progressive loss of motor neurons in the brain and spinal cord. This neurodegenerative syndrome shares pathobiological features with frontotemporal dementia and, indeed, many patients show features of both diseases. Many different genes and pathophysiological processes contribute to the disease, and it will be necessary to understand this heterogeneity to find effective treatments. In this Seminar, we discuss clinical and diagnostic approaches as well as scientific advances in the research fields of genetics, disease modelling, biomarkers, and therapeutic strategies.Copyright © 2017 Elsevier Ltd. All rights reserved.
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