• Semin Respir Crit Care Med · Jun 2017

    Review

    How Should We Treat HAP/VAP Caused by Carbapenemase-Producing Enterobacteriaceae?

    • Matteo Bassetti, Maddalena Peghin, Alessia Carnelutti, and Elda Righi.
    • Infectious Disesaes Clinic, Department of Medicine University of Udine and Santa Maria Misericordia Hospital, Udine, Italy.
    • Semin Respir Crit Care Med. 2017 Jun 1; 38 (3): 301-310.

    AbstractHospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) represent a common problem in hospital setting worldwide. Infections caused by carbapenem-resistant Enterobacteriaceae (CRE) are an emergent problem due to the lack of therapeutic options available, leading to significant increases in morbidity and mortality. CRE have frequently been reported both in HAP/VAP, but limited data regarding the optimal treatment strategy in this setting are available. This review focuses on the current epidemiology of CRE, with a specific focus on HAP/VAP. Moreover, we will suggest a possible strategy for the empiric and targeted treatment of HAP and VAP in which the involvement of CRE is suspected or is confirmed.

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