• Weili Zhang, Liya Nie, Lina Du, Wenyang Chen, Zhihong Wu, and Yiguang Jin.
• Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China; Anhui Medical University, Hefei 230001, China; Department of Ophthalmology, General Hospital of Armed Police Forces, Beijing 100039, China; Department of Ophthalmology, The First Affiliated Hospital of Huzhou University, Huzhou 313000, China.
• Burns. 2017 Dec 1; 43 (8): 1742-1747.

AimCorneal alkali burns are a severe disease and commonly encountered in the emergent clinic. A rapid medical treatment for the burn is very important. Gly-thymosin β4 (Gly-Tβ4) is a biomimic derivative of natural thymosin β4. The aim of this study is to evaluate the corneal recovery effects of Gly-Tβ4 topical therapy on alkali burns in rabbit corneas.MethodsRabbit alkali burns were induced with NaOH-contained filter paper. Phosphate-buffered solutions at pH 7.0, Gly-Tβ4 solutions, blank in situ hydrogels, and Gly-Tβ4in situ hydrogels were dropped on the burned corneas. The treatments were continued for 14 days. Conjunctiva hyperemia, corneal edema, intraeye extravasation, hemorrhaging, corneal neovascularization (CNV), and corneal opacity were observed. Corneal immunohistochemistry and histopathology were performed.ResultsGly-Tβ4 solutions led to a lower corneal burn index than the other regimens. Hydrogels may stimulate the burned corneas due to the direct contact of them, and prevent the rapid release of Gly-Tβ4. Gly-Tβ4 significantly inhibited CNV according to the images of the corneas, CNV areas, and CD31 expression. Furthermore, Gly-Tβ4 improved corneal epidermal recovery according to the histopathological result.ConclusionGly-Tβ4 solutions are a promising formulation for topical treatment of corneal alkali burns.Copyright © 2017 Elsevier Ltd and ISBI. All rights reserved.

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