• Norio Nakajima, Hitoshi Fukuda, Hiromasa Adachi, Natsuhi Sasaki, Makoto Yamaguchi, Yuto Mitsuno, Masashi Kitagawa, Fumihiko Horikawa, Kenichi Murao, and Keisuke Yamada.
• Department of Neurosurgery, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Japan. Electronic address: yu.nakaji129@gmail.com.
• World Neurosurg. 2017 Sep 1; 105: 591-598.

BackgroundPreoperative endovascular embolization of intracranial meningiomas denatures the tumor tissue, reduces intraoperative blood loss, and facilitates surgical removal. However, as most meningiomas are surgically removed within a few days after embolization, the effect of long-term volume reduction of the tumor due to the endovascular embolization remains unknown.MethodsFive patients with intracranial meningioma underwent endovascular embolization between January 2006 and December 2014 and were followed without surgical resection for >14 days. The reduction in tumor and peritumoral edema volumes on sequential head magnetic resonance imaging, along with the clinical symptoms, were retrospectively reviewed.ResultsAll the tumors indicated a 10%-30% volume reduction 30 days after embolization, which continued thereafter; no meningioma regrowth was observed for >90 days in 2 of 5 cases. Moreover, the peritumoral edema volume was reduced by 30%-70% at 30 days after embolization, and no subsequent increase was observed for >60 days in 4 of 5 cases. The neurologic symptoms related to the tumor mass effect improved after embolization.ConclusionsEndovascular embolization of intracranial meningiomas with n-butyl cyanoacrylate reduced the tumor and peritumoral edema volumes by 10%-30% and 30%-70%, respectively, within 30 days. Volume and edema reduction effect of embolization may last longer than expected, beyond the timing when most meningiomas are resected after embolization. In this study, we described our preliminary results of the volume reduction of intracranial meningiomas that were embolized using n-butyl cyanoacrylate and monitored without any surgical resection for >14 days. We believe that our study makes a significant contribution to the literature because we showed that volume and edema reduction effect of embolization may last longer than expected, beyond the timing when most meningiomas are resected after embolization.Copyright © 2017 Elsevier Inc. All rights reserved.

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