• J Extra Corpor Technol · Dec 2002

    Case Reports

    Argatroban in adult extracorporeal membrane oxygenation.

    • Nicklett Johnston, Michael Wait, and Lynne Huber.
    • Department of Cardiothoracic Surgery, The University of Texas Southwestern Medical Center at Dallas, 75390-8879, USA. johnstonr@sbcglobal.net
    • J Extra Corpor Technol. 2002 Dec 1; 34 (4): 281-4.

    AbstractThis case report addresses the use of Argatroban, an anticoagulant and thrombin inhibitor for treatment of thrombocytopenia in an adult patient on extracorporeal membrane oxygenation (ECMO). After 5 days on ECMO, the patient showed signs of heparin-induced thrombocytopenia (HIT) with a platelet count of 20K. Argatroban was initiated to decrease progression of HIT and continue treatment with ECMO proved to be successful. Given the occurrence of HIT with heparin therapy, a need for alternate drug therapy is required for patients requiring treatment with ECMO. The use of Argatroban in adult ECMO is outlined and includes dosage, monitoring, and patient treatment.

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