• Neurocritical care · Jun 2018

    Review

    The Role of Mast Cells in Intracerebral Hemorrhage.

    • Mustafa Yehya and Michel T Torbey.
    • Cerebrovascular and Neurocritical Care Division, Department of Neurology, Wexner Medical Center, The Ohio State University, 333 W. 10th Ave, Graves Hall, Rm. 3172, Columbus, OH, 43210, USA.
    • Neurocrit Care. 2018 Jun 1; 28 (3): 288-295.

    AbstractMast cells are first responders to intracerebral hemorrhage. They release potent mediators that can disrupt the blood-brain barrier promoting injury, vasogenic edema formation, and hematoma exacerbation. Also, mast cells recruit other inflammatory cells that maintain and amplify brain damage. Given their early role in the cascade of events in intracerebral hemorrhage, mast cells may offer an alternative target for antichemotactic interventions.

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