• Arch Orthop Trauma Surg · Sep 2017

    Randomized Controlled Trial

    Delayed union of humeral shaft fractures: comparison of autograft with and without platelet-rich plasma treatment: a randomized, single blinded clinical trial.

    • Carlos Acosta-Olivo, Abiel Garza-Borjon, Mario Simental-Mendia, Felix Vilchez-Cavazos, Yadira Tamez-Mata, and Victor Peña-Martinez.
    • Departamento de Ortopedia y Traumatología, Hospital Universitario "Dr. José E. Gonzalez", Universidad Autonoma de Nuevo Leon, Ave Madero y Gonzalitos s/n. Mitras Centro, 4to piso, CP: 64480, Monterrey, Mexico. dr.carlosacosta@gmail.com.
    • Arch Orthop Trauma Surg. 2017 Sep 1; 137 (9): 1247-1252.

    IntroductionDespite an adequate orthopedic treatment with functional bracing, some patients develop a delayed union in humeral shaft fractures. The objective of the present study was to determine the bone consolidation time among patients with delayed union of diaphyseal humeral fractures who were managed with locking compression plate (LCP) fixation combined with an iliac crest autograft using platelet-rich plasma (PRP) as a co-adjuvant.Materials And MethodsThis study was a controlled, randomized, experimental, longitudinal, comparative, prospective, blind clinical trial. Patients diagnosed with delayed union of a diaphyseal humeral fracture with at least 4 months of evolution were treated with an open reduction and LCP osteosynthesis combined with an iliac crest autograft. The experimental group also received PRP. The patients were assessed radiographically until 36 weeks of evolution.ResultsA total of 16 patients were included. Both groups had similar demographic characteristics. The patients treated with PRP had an earlier beginning of bone consolidation. Furthermore, these same patients exhibited bone consolidation at 19.9 weeks, on average, in contrast to 25.4 weeks in the control group.ConclusionsThe use of PRP promotes earlier bone consolidation in patients with delayed union of the humeral shaft.

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