• J Pain · Nov 2017

    Intensity dependence of auditory evoked potentials in primary dysmenorrhea.

    • Bingren Zhang, You Xu, Wei He, Jiawei Wang, Hao Chai, Chanchan Shen, Qisha Zhu, and Wei Wang.
    • Department of Clinical Psychology and Psychiatry, School of Public Health, Zhejiang University College of Medicine, Hangzhou, China.
    • J Pain. 2017 Nov 1; 18 (11): 1324-1332.

    AbstractSome studies suggest that women with primary dysmenorrhea have distinct emotional or personality features. For example, they might exaggerate their responses to external stimuli, such as to intensity-increasing auditory stimuli. Fifteen women with primary dysmenorrhea and 15 healthy women were invited to undergo tests of the intensity dependence of auditory evoked potentials (IDAEP), the Functional and Emotional Measure of Dysmenorrhea, and the Plutchik-van Praag Depression Inventory. Study participants with dysmenorrhea showed higher Functional and Emotional scale scores and stronger IDAEP. Regarding the IDAEP generation, the source inversion of N1 and P2 disclosed the activated bilateral superior temporal gyri, medial and superior prefrontal gyri in all participants, and additionally, the middle frontal gyri in dysmenorrhea patients. We report a pronounced IDAEP in primary dysmenorrhea, which indicates the decreased cerebral serotonergic innervations and points to increased activations in the prefrontal and frontal areas in the disorder.Copyright © 2017 American Pain Society. Published by Elsevier Inc. All rights reserved.

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