• Marc T Mathias, Michael B Horsley, Louise A Mawn, Stephen J Laquis, Kenneth V Cahill, Jill Foster, Malena M Amato, and Vikram D Durairaj.
• Rocky Mountain Lions Eye Institute, University of Colorado, Denver, Colorado, USA.
• Ophthalmology. 2012 Jun 1; 119 (6): 1238-43.

PurposeTo evaluate the epidemiologic and clinical features of orbital cellulitis caused by methicillin-resistant Staphylococcus aureus (MRSA).DesignMulticenter, retrospective case series.ParticipantsFifteen patients with culture-positive MRSA orbital cellulitis.MethodsAll recent cases of orbital cellulitis at several hospitals and surgical centers were reviewed, and cases with culture-positive MRSA from aspirates were identified. The data collected and analyzed retrospectively included patient demographics, medical history, presenting sign, imaging results, surgical procedure performed, surgical culture results, visual acuity at presentation and last follow-up, and duration of antibiotics.Main Outcome MeasuresPresenting sign, radiographic evidence of paranasal sinus disease, radiographic evidence of multiple orbital abscesses, presence or absence of antecedent upper respiratory infection, and final visual acuity.ResultsFifteen cases were identified. The mean patient age was 31.9 years (standard deviation, 24.2 years). Lid swelling was the presenting sign in 14 of 15 patients. No patients had a preceding upper respiratory infection, and only 1 patient had antecedent eyelid trauma. Only 3 of 15 patients had documented adjacent paranasal sinus disease on imaging. Lacrimal gland abscess or dacryoadenitis was the presenting finding in 5 of 15 patients. Multiple orbital abscesses were identified in 4 of 15 patients by computed tomography or magnetic resonance imaging. Fourteen of 15 cases required surgical intervention. Four of 15 cases had loss of visual acuity to light perception or worse. All 4 of these cases had a delay in referral for surgical intervention.ConclusionsIn these 15 patients with MRSA orbital cellulitis, the typical clinical setting of orbital cellulitis was absent; chiefly, there was no identified antecedent upper respiratory illness, nor was there a preceding traumatic injury. Lid swelling in the absence of recent upper respiratory illness, lacrimal gland focus, multiple orbital abscesses, and lack of adjacent paranasal sinus disease may be predictive factors that suggest MRSA as the causative organism of orbital cellulitis.Financial Disclosure(S)The author(s) have no proprietary or commercial interest in any materials discussed in this article.Copyright © 2012 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

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