Do low-grade and low-volume prostate cancers bear the hallmarks

The lancet oncology · Nov 2012

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Do low-grade and low-volume prostate cancers bear the hallmarks of malignancy?

Prostate cancer is generally multifocal and consists of a dominant focus-measured by tumour volume and deemed the index lesion-and one or more separate, secondary tumour foci of smaller volume. Much laboratory and clinical evidence has shown that we need to rethink how we regard low-grade and low-volume prostate lesions. In this Personal View, we discuss why small, low-grade Gleason pattern prostate lesions, which are currently designated as prostate cancer, could be regarded as non-malignant. These lesions either do not meet the criteria of the hallmarks of cancer or robust evidence that they do so is absent, by contrast with large lesions with a high Gleason grade, which seem to cause most metastatic disease.

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- Hashim Uddin Ahmed, Manit Arya, Alex Freeman, and Mark Emberton.
- Division of Surgery and Interventional Science, University College London, London, UK. hashim.ahmed@ucl.ac.uk
- Lancet Oncol. 2012 Nov 1; 13 (11): e509-17.
AbstractProstate cancer is generally multifocal and consists of a dominant focus-measured by tumour volume and deemed the index lesion-and one or more separate, secondary tumour foci of smaller volume. Much laboratory and clinical evidence has shown that we need to rethink how we regard low-grade and low-volume prostate lesions. In this Personal View, we discuss why small, low-grade Gleason pattern prostate lesions, which are currently designated as prostate cancer, could be regarded as non-malignant. These lesions either do not meet the criteria of the hallmarks of cancer or robust evidence that they do so is absent, by contrast with large lesions with a high Gleason grade, which seem to cause most metastatic disease.Copyright © 2012 Elsevier Ltd. All rights reserved.

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Do low-grade and low-volume prostate cancers bear the hallmarks of malignancy?

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