• Lonneke A van Vught, Rebecca Holman, Evert de Jonge, Nicolette F de Keizer, and Tom van der Poll.
• 1Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. 2Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. 3Department of Medical Informatics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. 4NICE foundation, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. 5Department of Intensive Care Medicine, Leiden University Medical Center, Leiden, the Netherlands. 6Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
• Crit. Care Med. 2017 Oct 1; 45 (10): e1026-e1035.

ObjectivesTo determine the association of pre-existing diabetes, hyperglycemia, and hypoglycemia during the first 24 hours of ICU admissions with 90-day mortality in patients with sepsis admitted to the ICU.DesignWe used mixed effects logistic regression to analyze the association of diabetes, hyperglycemia, and hypoglycemia with 90-day mortality (n = 128,222).SettingAll ICUs in the Netherlands between January 2009 and 2014 that participated in the Dutch National Intensive Care Evaluation registry.PatientsAll unplanned ICU admissions in patients with sepsis.InterventionsThe association between 90-day mortality and pre-existing diabetes, hyperglycemia, and hypoglycemia, corrected for other factors, was analyzed using a generalized linear mixed effect model.Measurements And Main ResultsIn a multivariable analysis, diabetes was not associated with increased 90-day mortality. In diabetes patients, only severe hypoglycemia in the absence of hyperglycemia was associated with increased 90-day mortality (odds ratio, 2.95; 95% CI, 1.19-7.32), whereas in patients without pre-existing diabetes, several combinations of abnormal glucose levels were associated with increased 90-day mortality.ConclusionsIn the current retrospective large database review, diabetes was not associated with adjusted 90-day mortality risk in critically ill patients admitted with sepsis.

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