• Gino Vissers, Jasmeet Soar, and Koenraad G Monsieurs.
• Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium; Department of Emergency Medicine, Antwerp University Hospital, Edegem, Belgium. Electronic address: gino.vissers@student.uantwerpen.be.
• Resuscitation. 2017 Oct 1; 119: 5-12.

AimThe optimal ventilation rate during cardiopulmonary resuscitation (CPR) with a tracheal tube is unknown. We evaluated whether in adults with cardiac arrest and a secure airway (tracheal tube), a ventilation rate of 10min-1, compared to any other rate during CPR, improves outcomes.MethodsA systematic review up to 14 July 2016. We included both adult human and animal studies. A GRADE (Grades of Recommendation, Assessment, Development and Evaluation) approach was used to evaluate the quality of evidence for each outcome.ResultsWe identified one human observational study with 67 patients and ten animal studies (234 pigs and 30 dogs). All studies carried a high risk of bias. All studies evaluated for return of spontaneous circulation (ROSC). Studies showed no improvement in ROSC with a ventilation rate of 10 min-1 compared to any other rate. The evidence for longer-term outcomes such as survival to discharge and survival with favourable neurological outcome was very limited.ConclusionA ventilation rate recommendation of 10 min-1 during adult CPR with a tracheal tube and no pauses for chest compression is a very weak recommendation based on very low quality evidence.Copyright © 2017 Elsevier B.V. All rights reserved.

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