• Pinaki Dutta, Sivashanmugam Dhandapani, Narendra Kumar, Prakamya Gupta, Chirag Ahuja, and Kanchan Kumar Mukherjee.
• Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
• World Neurosurg. 2017 Nov 1; 107: 1044.e5-1044.e10.

BackgroundAngiogenesis and vascular endothelial growth factor (VEGF) have recently been implicated in animal and clinical models of radiation-induced optic nerve, retinal, and brain necrosis. Although there are isolated case reports of anti-VEGF therapy with bevacizumab for management of radiation-induced brain necrosis, there are little data defining its role in radiation-induced optic nerve damage.Patients And MethodsThis study included patients with a sellar-suprasellar tumor who underwent intensity-modulated or Gamma Knife radiotherapy and developed radiation-induced optic neuritis (RION) refractory to 3 weeks of glucocorticoid therapy who received bevacizumab 5 mg/kg intravenously as initial dose, followed by subsequent doses of 10 mg/kg.ResultsHere we report 3 patients with sellar-suprasellar lesions undergoing conventional radiation therapy (2 cases) or Gamma Knife surgery (1 case) who had benefitted from anti-VEGF therapy following radiation-induced optic nerve damage.ConclusionsEarly bevacizumab therapy in steroid-refractory RION shows gratifying results.Copyright © 2017 Elsevier Inc. All rights reserved.

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