• Chih-Ta Lin, Katrina Ducis, Suzanne Tucker, and Bruce Tranmer.
• Department of Neurosurgery, Indiana University School of Medicine, Muncie, Indiana. Electronic address: clin@goodmancampbell.com.
• World Neurosurg. 2017 Nov 1; 107: 1049.e9-1049.e12.

BackgroundMetastatic angiosarcoma to the brain is a rare entity without an established management protocol.Case DescriptionA man with primary cardiac angiosarcoma presented with a rare brain metastasis. The patient underwent successful resection of the brain metastasis and was initiated on chemotherapy only for his systemic disease. The patient did not develop local recurrence. A review of primary and metastatic central nervous system angiosarcoma, its pathologic features, clinical disease course, treatment strategies, and genomics is also provided.ConclusionsAngiosarcomas are rare tumors that are difficult to treat. Gross total resection of a central nervous system metastasis is recommended before initiation of adjuvant chemotherapy or radiation therapy. Close follow-up is still required given the propensity for continued metastasis of these tumors. Future treatments may be developed based on the genomics of angiosarcomas.Copyright © 2017 Elsevier Inc. All rights reserved.

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