• Transfusion · Apr 2012

    Review

    How do I transfuse platelets (PLTs) to reverse anti-PLT drug effect?

    • Ravi Sarode.
    • Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9073, USA. ravi.sarode@utsouthwestern.edu
    • Transfusion. 2012 Apr 1; 52 (4): 695-701; quiz 694.

    AbstractAntiplatelet agents (APAs) are commonly used in clinical practice to either treat or prevent arterial thrombotic disorders in patients at high risk. The newer APAs are more potent with higher bleeding risk profiles. Patients who present with serious bleeds or need urgent surgical interventions while on APAs may require reversal of these agents' effect on PLTs. Currently, there are no guidelines for management of such patients. This article describes my approach to PLT transfusion or use of pharmacologic agents in such clinical scenarios based solely on personal experience and very limited published data.© 2011 American Association of Blood Banks.

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