• Kevin Phan, Adam A Dmytriw, Julian Maingard, Hamed Asadi, Christoph J Griessenauer, Wyatt Ng, Kitso Kewagamang, Ralph J Mobbs, Justin M Moore, Christopher S Ogilvy, and Ajith J Thomas.
• NeuroSpine Surgery Research Group, Sydney, Australia. Electronic address: kphan.vc@gmail.com.
• World Neurosurg. 2017 Dec 1; 108: 850-858.e2.

BackgroundTo date, no randomized trial has directly addressed the question of whether intravenous (IV) tissue plasminogen activator (tPA) improves outcomes in IV tPA-eligible patients who will eventually undergo endovascular therapy (EVT), or whether a direct EVT strategy is equally effective. We performed a systematic review and meta-analysis to compare the efficacy and safety of direct EVT versus endovascular treatment with IV tPA (EVT+IV tPA) in adults with acute ischemic stroke.MethodsWe performed electronic searches of 6 databases from their inception to January 2017. Data were extracted and analyzed according to predefined clinical endpoints.ResultsTwelve comparative studies, comprising 1275 patients in the EVT-only arm and 1340 patients in the combined EVT+IV tPA arm, were included. The rates of good functional outcomes (modified Rankin Scale score ≤2) and 90-day mortality were not statistically significantly different between the EVT and EVT+IV tPA arms (44% vs. 48%; odds ratio [OR], 0.80; 95% confidence interval [CI], 0.64-1.002; P = 0.052 and 20.4% vs. 19.4%, OR 1.19; 95% CI, 0.83-1.71; P = 0.34, respectively). The rate of symptomatic intracranial hemorrhage also was not significantly different between the EVT and EVT+IV tPA arms (3.7% vs. 3.8%; OR, 0.98; 95% CI, 0.65-1.48; P = 0.91). There were no between-group differences in the rates of other complications.ConclusionsNo significant differences between the 2 groups were found in terms of favorable functional outcome, mortality rate, or complications based on contemporary endovascular therapies.Copyright © 2017 Elsevier Inc. All rights reserved.

27 keywords...

hide…