• Annals of neurology · Oct 2012

    Acid-sensing ion channel 1: a novel therapeutic target for migraine with aura.

    • Philip R Holland, Simon Akerman, Anna P Andreou, Nazia Karsan, John A Wemmie, and Peter J Goadsby.
    • Headache Group, Department of Neurology, University of California at San Francisco, San Francisco, CA 94115, USA.
    • Ann. Neurol. 2012 Oct 1; 72 (4): 559-63.

    ObjectiveMigraine with aura is a severe debilitating neurological disorder with few relatively specific therapeutic options.MethodsWe used amiloride, a blocker of epithelial sodium channels, to evaluate its pharmacological potential and explored the biology of a potential mechanism of action in well-established experimental models.ResultsAmiloride was shown to block cortical spreading depression, the experimental correlate of aura, and inhibited trigeminal activation in in vivo migraine models, via an acid-sensing ion channel 1 mechanism. Remarkably, amiloride then demonstrated good clinical efficacy in a small open-labeled pilot study of patients, reducing aura and headache symptoms in 4 of 7 patients with otherwise intractable aura.InterpretationThe observations here identify an entirely novel treatment strategy for migraine.Copyright © 2012 American Neurological Association.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…