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J Int Neuropsychol Soc · May 2012
Verbal fluency in patients receiving bilateral versus left-sided deep brain stimulation of the subthalamic nucleus for Parkinson's disease.
- Rickard L Sjöberg, Elin Lidman, Björn Häggström, Marwan I Hariz, Jan Linder, Anna Fredricks, and Patric Blomstedt.
- Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden. rickard.l.sjoberg@gmail.com
- J Int Neuropsychol Soc. 2012 May 1; 18 (3): 606-11.
AbstractThe purpose of this study was to investigate the relative effects of unilateral (left-sided) versus bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) on verbal fluency. To do this, 10 Parkinson's disease patients with predominantly bilateral motor symptoms who received bilateral STN DBS were compared with 6 patients suffering from predominantly unilateral symptoms who received STN DBS on the left side only. The results suggest that unilateral STN DBS of the speech dominant hemisphere is associated with significantly less declines in measures of verbal fluency as compared to bilateral stimulation.
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