• Zulfi Haneef, Agatha Lenartowicz, Hsiang J Yeh, Jerome Engel, and John M Stern.
• Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA. haneef@bcm.edu
• Epilepsy Behav. 2012 Nov 1; 25 (3): 350-7.

AbstractThe default mode network (DMN) is composed of cerebral regions involved in conscious, resting state cognition. The hippocampus is an essential component of this network. Here, the DMN in TLE is compared to control subjects to better understand its involvement in TLE. We performed resting state connectivity analysis using regions of interest (ROIs) in the retrosplenium/precuneus (Rsp/PCUN) and the ventro-medial pre-frontal cortex (vmPFC) in 36 subjects (11 with right TLE, 12 with left TLE, 13 controls) to delineate the posterior and anterior DMN regions respectively. We found reduced connectivity of the posterior to the anterior DMN in patients with both right and left TLE. However, the posterior and anterior networks were found to be individually preserved. Lateralization of TLE affects the DMN with left TLE demonstrating more extensive networks. These DMN changes may be relevant to altered cognition and memory in TLE and may be relevant to right vs. left TLE differences in cognitive involvement.Published by Elsevier Inc.

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