• Gail S Bell, Jane de Tisi, Juan Carlos Gonzalez-Fraile, Janet L Peacock, Andrew W McEvoy, HarknessWilliam F JWFJDepartment of Clinical and Experimental Epilepsy, NIHR University College London Hospitals Biomedical Research Centre, UCL Institute of Neurology, London, UK., Jacqueline Foong, Rebecca A Pope, Beate Diehl, Josemir W Sander, and John S Duncan.
• Department of Clinical and Experimental Epilepsy, NIHR University College London Hospitals Biomedical Research Centre, UCL Institute of Neurology, London, UK.
• J. Neurol. Neurosurg. Psychiatr. 2017 Nov 1; 88 (11): 933-940.

ImportanceSurgical treatment can bring seizure remission in people with focal epilepsy but requires careful selection of candidates.ObjectivesTo determine which preoperative factors are associated with postoperative seizure outcome.DesignWe audited seizure outcome of 693 adults who had resective epilepsy surgery between 1990 and 2010 and used survival analysis to detect preoperatively identifiable risk factors of poor seizure outcome.ResultsSeven factors were significantly associated with increased probability of recurrence of seizures with impaired awareness postsurgery: MRI findings (eg, HR adjusted for other variables in the model 2.5; 95% CI 1.6 to 3.8 for normal MRI compared with hippocampal sclerosis), a history of secondarily generalised convulsive seizures (2.3; 95% CI 1.7 to 3.0 for these seizures in the previous year vs never), psychiatric history (1.3; 95% CI 1.1 to 1.7), learning disability (1.8; 95% CI 1.2 to 2.6) and extratemporal (vs temporal) surgery (1.4; 95% CI 1.02, 2.04). People with an older onset of epilepsy had a higher probability of seizure recurrence (1.01; 95% CI 1.00, 1.02) as did those who had used more antiepileptic drugs (1.05; 95% CI 1.01 to 1.09). Combinations of variables associated with seizure recurrence gave overall low probabilities of 5-year seizure freedom (eg, a normal MRI and convulsive seizures in the previous year has a probability of seizure freedom at 5 years of approximately 0.19).Conclusions And RelevanceReadily identified clinical features and investigations are associated with reduced probability of good outcome and need consideration when planning presurgical evaluation.© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

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