• World Neurosurg · Dec 2017

    Review Case Reports

    Case report of regression of recurrent high grade glioma with temozolomide, dexamethasone and levetiracetam and review of literature.

    • Ajaya Kumar A and Abu Abraham Koshy.
    • Department of Neurosurgery, Muthoot Healthcare, Kozhencherry, Kerala, India. Electronic address: drajayakumara@gmail.com.
    • World Neurosurg. 2017 Dec 1; 108: 990.e11-990.e16.

    BackgroundTreatment options for recurrent glioma of the brain include chemotherapy, radiotherapy, surgery, and palliation. Temozolomide appears to be effective in patients with recurrent high-grade gliomas.Case DescriptionA middle-aged woman presented with a high-grade glioma of corpus callosum. The tumor, a grade 3 anaplastic oligodendroglioma, was excised, and chemoradiotherapy was administered. The patient presented with significant recurrence 5 years later. Repeat surgery and radiation were suggested but refused. She was given temozolomide and dexamethasone intermittently, and levetiracetam was continued. Magnetic resonance imaging performed at 10-month follow-up showed 90% remission.ConclusionsThere are a few reports in the literature of similar response to temozolomide and levetiracetam. Similar reports give more hope in the treatment of recurrent high grade glioma.Copyright © 2017 Elsevier Inc. All rights reserved.

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