• Critical care clinics · Oct 2017

    Review

    Medication Complications in Extracorporeal Membrane Oxygenation.

    • Ami G Shah, Michelle Peahota, Brandi N Thoma, and Walter K Kraft.
    • Department of Pharmacy, Thomas Jefferson University Hospital, 111 South 11th Street, Suite 2260, Philadelphia, PA 19107, USA. Electronic address: amishah1221@gmail.com.
    • Crit Care Clin. 2017 Oct 1; 33 (4): 897-920.

    AbstractThe need for extracorporeal membrane oxygenation (ECMO) therapy is a marker of disease severity for which multiple medications are required. The therapy causes physiologic changes that impact drug pharmacokinetics. These changes can lead to exposure-driven decreases in efficacy or increased incidence of side effects. The pharmacokinetic changes are drug specific and largely undefined for most drugs. We review available drug dosing data and provide guidance for use in the ECMO patient population.Published by Elsevier Inc.

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