• Masahiko Kawaguchi, Masakazu Kuro, Hisatoshi Ohsumi, Toshito Nakajima, Yoshihiro Kuriyama, and Jun Karasawa.
• Department of Anesthesiology, National Cardiovascular Center, 5-7-1 Fujishirodai Suita, 565, Osaka, Japan.
• J Anesth. 1994 Mar 1; 8 (1): 60-63.

AbstractWe assessed the local cerebral blood flow (LCBF) in 40 patients under fentanyl-diazepam anesthesia. The measurement of LCBF was made using 50%-70% stable xenon with 20 min of inhalation interval and a shuttle method for computed tomography imaging. All patients were anesthetized with 5.95±1.76 μg·kg-1 fentanyl and 0.22±0.07 mg·kg-1 diazepam under mechanical ventilation during CBF measurement. The values and distribution of LCBF on non-affected hemisphere appeared to be unaltered by fentanyldiazepam anesthesia. We also assessed the cerebral carbon dioxide reactivity in 6 patients. The cerebral carbon dioxide reactivity, expressed as percentage change in LCBF per unit change in arterial carbon dioxide partial pressure, was 5.39±1.07, and there were no significant differences of reactivity among regions studied. In conclusion, we showed reference values of LCBF and carbon dioxide reactivity, measured by stable xenon-enhanced computed tomography, in patients under fentanyl-diazepam anesthesia. Carbon dioxide reactivity was preserved in all regions including gray matter, white matter, and basal ganglia.

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