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The lancet oncology · Jul 2013
ReviewVertebral compression fracture after stereotactic body radiotherapy for spinal metastases.
- Arjun Sahgal, Cari M Whyne, Lijun Ma, David A Larson, and Michael G Fehlings.
- Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada. arjun.sahgal@sunnybrook.ca
- Lancet Oncol. 2013 Jul 1; 14 (8): e310-20.
AbstractThe use of stereotactic body radiotherapy for metastatic spinal tumours is increasing. Serious adverse events for this treatment include vertebral compression fracture (VCF) and radiation myelopathy. Although VCF is a fairly low-risk adverse event (approximately 5% risk) after conventional radiotherapy, crude risk estimates for VCF after spinal SBRT range from 11% to 39%. In this Review, we summarise the evidence and predictive factors for VCF induced by spinal SBRT, review the pathophysiology of VCF in the metastatic spine, and discuss strategies used to prevent and manage this potentially disabling complication. Copyright © 2013 Elsevier Ltd. All rights reserved.
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