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Anesthesia and analgesia · Nov 2017
Randomized Controlled TrialEffect of High Inspiratory Oxygen Fraction on Endothelial Function in Healthy Volunteers: A Randomized Controlled Crossover Pilot Study.
- Mikkel Hjordt Holm Larsen, Sarah Ekeloef, Dunja Kokotovic, Anne-Marie Schou-Pedersen, Jens Lykkesfeldt, and Ismail Gögenür.
- From the *Department of Surgery, Center for Surgical Science, Zealand University Hospital, Koege, Denmark; and †Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.
- Anesth. Analg. 2017 Nov 1; 125 (5): 1793-1796.
AbstractIt has been suggested that high inspiratory oxygen concentrations during anesthesia may be associated with higher postoperative mortality due to endothelial dysfunction. A randomized controlled crossover study was conducted with 25 healthy male volunteers. They inhaled an oxygen concentration of 30% and 80%. The endothelial function was assessed using noninvasive digital pulse amplitude tonometry (EndoPAT) supported by endothelial biomarkers. The difference in endothelial function between the 2 treatments was 0.05 (95% confidence interval, -0.36 to 0.27; P = .77). Endothelial biomarkers were unaffected. Inhalation of a high oxygen fraction in healthy volunteers did not result in a significant reduction of endothelial function.
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