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Br J Clin Pharmacol · Feb 1980
Elevated blood histamine levels and mast cell degranulation in solar urticaria.
- J L Hawk, R A Eady, A V Challoner, A Kobza-Black, T M Keahey, and M W Greaves.
- Br J Clin Pharmacol. 1980 Feb 1; 9 (2): 183-6.
Abstract1 Ultraviolet radiation (UVR)-induced wealing was studied in four patients with solar urticaria, whose measured action spectra were within the range 300 to 700 nm. 2 Elevated histamine levels were found in blood draining wealed skin in all four patients. 3 Histological and electron microscopial studies of the irradiated skin showed evidence of mast cell degranulation. 4 These findings demonstrate an association between histamine release from mast cells and wealing in solar urticaria, and should encourage evaluation of drugs which suppress histamine release in this disorder.
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