• World Neurosurg · Dec 2017

    Impact of symptomatic metastatic spinal cord compression on survival of patients with non-small cell lung cancer.

    • Gustavo Telles da Silva, Anke Bergmann, and ThulerLuiz Claudio SantosLCSResearch Center, National Cancer Institute and Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: lthuler@gmail.com..
    • Research Center, National Cancer Institute and Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil.
    • World Neurosurg. 2017 Dec 1; 108: 698-704.

    ObjectivesNon-small-cell lung cancer (NSCLC) is one of the most common primary tumor sites among patients with metastatic spinal cord compression (MSCC). This disorder is related to neurologic dysfunction and can reduce the quality of life, but the association between MSCC and death is unclear. The aim of this study was to analyze the impact of the occurrence of symptomatic MSCC on overall survival of patients with NSCLC.MethodsA cohort study was carried out involving 1112 patients with NSCLC who were enrolled between 2006 and 2014 in a single cancer center. Clinical and sociodemographic data were extracted from the physical and electronic records. Survival analysis of patients with NSCLC was conducted using the Kaplan-Meier method. A log-rank test was used to assess differences between survival curves. Cox proportional hazards regression analyses were carried out to quantify the relationship between the independent variable (MSCC) and the outcome (overall survival).ResultsDuring the study period, the incidence of MSCC was 4.1%. Patients who presented with MSCC were 1.43 times more likely to die than were those with no history of MSCC (hazard ratio, 1.43; 95% confidence interval [CI], 1.03-2.00; P = 0.031). The median survival time was 8.04 months (95% CI, 6.13-9.96) for those who presented MSCC and 11.95 months (95% CI, 10.80-13.11) for those who did not presented MSCC during the course of disease (P = 0.002).ConclusionsMSCC is an important and independent predictor of NSCLC worse survival. This effect was not influenced by sociodemographic and clinical factors.Copyright © 2017 Elsevier Inc. All rights reserved.

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