• Damir Nizamutdinov, Eileen M Stock, Jad A Dandashi, Eliana A Vasquez, Ying Mao, Samantha Dayawansa, Jun Zhang, Erxi Wu, Ekokobe Fonkem, and Jason H Huang.
• Texas A&M Health Science Center College of Medicine, Temple, Texas, USA; Department of Neurosurgery, Baylor Scott and White Health Care, Temple, Texas, USA.
• World Neurosurg. 2018 Jan 1; 109: e67e74e67-e74.

ObjectiveGlioblastoma multiforme (GBM) is an aggressive primary brain tumor with dismal survival. This study aims to examine the prognostic value of primary tumor sites and race on survival outcomes.MethodsPatient data obtained from the Scott and White Hospital Brain Tumor Registry (1976-2013) were stratified according to sex, age, race, primary tumor site, vital status, and survival.ResultsOf the 645 patients, 580 (89.9%) were diagnosed with GBM not otherwise specified (GBM NOS), 57 (8.8%) with GBM, and 8 (1.2%) with giant-cell GBM. Most were male (53.5%), aged 50 years or older (78.7%). The white population had the highest GBM prevalence (87.1%) and the lowest overall survival versus all other race groups (6.6% vs. 30.1%; P < 0.01). The black population had a relatively low prevalence of GBM (5.9%) and the greatest overall survival versus all others (47.4% vs. 7.3%; P < 0.01). Primary tumor sites located in the temporal (25.8% vs. 20.2%; P = 0.03), occipital (8.1% vs. 2.9%; P = 0.05), and parietal lobes (24.2% vs. 20.8%; P = 0.05) had a greater occurrence in surviving individuals. The overall survival for men versus women was (62.9% vs. 37.1%; P = 0.12).ConclusionsBlack racial background and temporal, occipital, or parietal primary tumor sites are suggestive of positive survival outcomes. Conversely, white racial background with primary tumor sites in the brain overlapping and NOS areas seem to be associated with negative outcomes and decreased survival. Thus, racial background and primary tumor site may be useful prognostic factors in patients with GBM.Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

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