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J. Neurol. Neurosurg. Psychiatr. · Feb 2018
ReviewAnti-inflammatory approaches to ischaemic stroke prevention.
- Peter J Kelly, Sean Murphy, Sarah Coveney, Francisco Purroy, Robin Lemmens, Georgios Tsivgoulis, and Chris Price.
- Health Research Board Irish Stroke Clinical Trials Network and Mater University Hospital/University College Dublin, Dublin, Ireland.
- J. Neurol. Neurosurg. Psychiatr. 2018 Feb 1; 89 (2): 211-218.
AbstractStroke is a major cause of neurological morbidity and mortality. Atherosclerosis is a major contributor to first and recurrent stroke. A growing evidence base indicates that inflammation is a key process in the pathogenesis of atherosclerosis, leading to thromboembolic events. In this review, we summarise the evidence linking inflammation to stroke risk and discuss clinical trials addressing the 'inflammation hypothesis' in coronary disease and stroke. Trial registration number CONVINCE trial ClinicalTrials.gov number; NCT 02898610; Pre-results.© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
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