• J. Thorac. Cardiovasc. Surg. · Feb 2018

    Randomized Controlled Trial

    A prospective randomized trial of the cut-and-sew Maze procedure in patients undergoing surgery for rheumatic mitral valve disease.

    • Huishan Wang, Jinsong Han, Zengwei Wang, Zongtao Yin, Zhigang Liu, Yan Jin, and Hongguang Han.
    • Department of Cardiovascular Surgery, General Hospital of Shenyang Military Area Command, Shenyang, China. Electronic address: huishanwang@hotmail.com.
    • J. Thorac. Cardiovasc. Surg. 2018 Feb 1; 155 (2): 608-617.

    ObjectiveTo evaluate the safety and efficacy of the addition of the cut-and-sew Maze III procedure (CSM) for mitral valve replacement (MVR) in patients with atrial fibrillation (AF) associated with rheumatic mitral valve disease (RMVD).MethodsA total of 130 patients with persistent or long-standing persistent AF associated with RMVD were assigned at random to either the CSM plus MVR (Maze III) group or MVR alone (non-Maze) group. The primary endpoint was a composite of freedom from stroke and death at 1 year.ResultsThere were no significant differences between the Maze III and non-Maze groups in terms of major complications and in-hospital mortality. One-year freedom from stroke or death was better in the Maze III group compared with the non-Maze group (P = .0028; hazard ratio, 0.2653; 95% confidence interval, 0.1122 to 0.6270). The risk of AF recurrence in the Maze III group was 0.002-fold that in non-Maze group (P = .000).ConclusionsAddition of the CSM to an MVR procedure can decrease the risk of stroke or death and high sinus rhythm at 1 year without increasing the operative risk. CSM is a safe and effective approach to treating AF associated with RMVD.Copyright © 2017 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.

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