• Martin Schmidt, Uwe Dorwarth, Dietrich Andresen, Johannes Brachmann, Karlheinz Kuck, Malte Kuniss, Stephan Willems, Thomas Deneke, Jürgen Tebbenjohanns, Jin-Hong Gerds-Li, Stefan Spitzer, Jochen Senges, Matthias Hochadel, and Ellen Hoffmann.
• Department of Cardiology, Klinikum Bogenhausen, Munich, Germany. Electronic address: mschmidtco@arcor.de.
• Heart Rhythm. 2016 Apr 1; 13 (4): 836-44.

BackgroundAlthough radiofrequency (RF) ablation has long been the standard of care for atrial fibrillation (AF) ablation, cryoballoon technology has emerged as a feasible approach with promising results. Prospective multicenter registry data referring to both ablation technologies in AF ablation are lacking so far.ObjectiveThe purpose of this study was to report data from the German ablation registry with respect to efficacy and safety in pulmonary vein ablation with different energy sources for paroxysmal AF after 1-year follow-up.MethodsA total of 2306 patients with symptomatic paroxysmal AF from the German ablation registry were included in this analysis. The cohort was divided into two groups according to the ablation energy source used: cryoballoon and RF ablation. MACCE was defined as a combination of death, myocardial infarction, or stroke.ResultsAF recurrence rate after a single ablation procedure at 1 year follow-up was not significantly different between the two groups (45.8% after cryoablation and 45.4% after RF ablation, P = .87). Also, the rate of patients without AF recurrence and free of antiarrhythmic drug at 12-month follow-up was similar (cryoablation 44.2% and RF 41.4%, P = .25). MACCE occurred with an incidence of 0.7% within 500 days after cryoablation and 1.4% after RF ablation (P = .30). Persistent phrenic nerve palsy was more common after cryoablation compared to RF ablation (1.1% vs. 0.3%, P <.05).ConclusionAF recurrence rate at 1-year follow-up was similar in RF ablation compared to cryoablation, whereas the spectrum and relevance of complications were significantly different between the two ablation methods. This finding might influence the choice of ablation method offered to the individual paroxysmal AF patient.Copyright © 2016 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

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